A Review of Glycated Albumin as an Intermediate Glycation Index for Controlling Diabetes

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A review of glycated albumin as an intermediate glycation index for controlling diabetes.

INTRODUCTION This article reviews glycated albumin (GA) as a potential intermediate-term glycation index to fill the gap between self-monitoring of blood glucose (SMBG) and hemoglobin A1c testing in diabetes management. The introduction gives an assessment of available short-, medium-, and long-term glycemic indicators. METHODOLOGIES AND UTILITY: Methods of GA measurement are summarized, and th...

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The conventional glycemic indices used in management of diabetic patients includes A1c, fructosamine, 1,5-anhydroglucitol, and glycated albumin (GA). Among these indices, A1c is currently used as the gold standard. However, A1c cannot reflect the glycemic change over a relatively short period of time, and its accuracy is known to decrease when abnormalities in hemoglobin metabolism, such as ane...

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Diabetes mellitus (DM) is a chronic and metabolic disease that presents a high global incidence. Glycated hemoglobin (A1C) is the reference test for long-term glucose monitoring, and it exhibits an association with diabetic chronic complications. However, A1C is not recommended in clinical situations which may interfere with the metabolism of hemoglobin, such as in hemolytic, secondary or iron ...

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Albumin is the most common protein found in serum, making up about 80% concentration of the circulating blood protein. It is replaced in the body approximately every 20-25 days. As with other proteins in the body, it is subject to non-enzymatic glycation by excess sugar. The glycation process is a condensation reaction between carbohydrate and free amino acid at the amino terminus of proteins o...

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ژورنال

عنوان ژورنال: Journal of Diabetes Science and Technology

سال: 2008

ISSN: 1932-2968,1932-2968

DOI: 10.1177/193229680800200620